Integ Opt

Downlo have recently developed a novel optical technology, partial wave spectroscopic (PWS) microscopy, is exquisitely sensitive to the nanoarchitectural manifestation of the genetic/epigenetic alterations of arcinogenesis. Our approach was to screen for lung cancer by assessing the cheek cells based on emergnetic/epigenetic data which suggests that the buccal epithelium is altered in lung field carcinogenesis. rformed PWS analysis from microscopically normal buccal epithelial brushings from smokers with and t lung cancer (n = 135). The PWS parameter, disorder strength of cell nanoarchitecture (Ld), was mark50%) elevated in patients harboring lung cancer compared with neoplasia-free smokers. The perforcharacteristic was excellent with an area under the receiver operator characteristic curve of >0.80 as equivalent for both disease stage (early versus late) and histologies (small cell versus non–small cell ancers). An independent data set validated the findings with only a minimal degradation of performance teristics. Our results offer proof of concept that buccal PWS may potentially herald a minimally intrucharac sive prescreening test that could be integral to the success of lung cancer population screening programs. Cancer Res; 70(20); 7748–54. ©2010 AACR.